研究成果 |
主持科研项目： 1. Trim21泛素化Snail调控乳腺癌细胞EMT的表观遗传机制（81802909），国家自然科学基金青年项目，2019.01-2021.12，项目负责人。 2. LSD1调控乳腺癌发生发展的机制（BX201600065），博士后创新人才支持计划，2016.09-2018.09，项目负责人。 3. LSD1协同EZH2调控乳腺癌细胞组蛋白甲基化的机制研究（2017M611315），第61批中国博士后科学基金面上资助项目，2017.09-2019.09，项目负责人。 4. Trim21泛素化Snail调控乳腺癌细胞EMT的表观遗传机制（20190103069JH），吉林省科技发展计划优秀青年人才基金项目，项目负责人。 代表性期刊论文： 1.Jin Y, Shenoy AK, Doernberg S, Chen H, Luo H, Shen H, Lin T, Tarrash M, Cai Q, Hu X, Fiske R, Chen T, Wu L, Mohammed KA, Rottiers V, Lee SS, Lu J.#, #, ,,,,,,,,.Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation. Oncotarget. 2016; 7(18): 25113- 24. 3. , , , , , . Cancer-associated mutation abolishes the impact of TRIM21 on the invasion of breast cancer cells. 2020; 142:782-789. 4., , , , , , . TRIM21 mediates ubiquitination of Snail and modulates epithelial to mesenchymal transition in breast cancer cells. 2019; 124:846-853. 5.#,#,,,,,. LSD1 collaborates with EZH2 to regulate expression of interferon-stimulated genes. 2017; 88:728-737. 6.#,,,,,,. LSD1 knockdown reveals novel histone lysine methylation in human breast cancer MCF-7 cells. 2017; 92:896-904. 7.Shenoy AK,,,,,,,,,,,. Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells. J Clin Invest. 2016; 126(11):4174-4186. 8 , , , , , , , , , . Semiconducting Polymer Nanocavities: Porogenic Synthesis, Tunable Host- Guest Interactions, and Enhanced Drug/siRNA Delivery. Small. 2018;14(21): e18002 39. 9. Hu X,Xiang D, Xie Y, Tao L, Zhang Y,Jin Y, Pinello L, Wan Y, Yuan G, Li Z.LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression. Oncogene. 2019; 38(44):7017-7034. 10.,,,,,,,,,,,,,,,. MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial to Mesenchymal Transition. Cell Rep. 2016;15(12):2665-78. 11. . Size- matching hierarchical micropillar arrays for detecting circulating tumor cells in breast cancer patients' whole blood. 2019; 11(14):6677-6684. 12 Kamarajugadda S, Cai Q, Chen H, Nayak S, Zhu J, He M,Jin Y, Zhang Y, Ai L, Martin SS, Tan M, Lu J.,, , ,,,,., , , , , . Extracts and components of Ficus carica leaves suppress survival, cell cycle, and migration of triple-negative breast cancer MDA-MB-231 cells. 2018; 11:4377-4386. |
